Figure 2. Position and interspecies conservation of FOXD3 variants. Schematic of the FOXD3 protein showing the forkhead domain (shaded)
and positions of the amino acid variants affecting conserved regions; variants that showed a statistically significant association
with the patient population (see text) are marked with an asterisk (A). Amino acid alignments of vertebrate FOXD3 proteins for the corresponding regions (B).