Figure 5. SD-OCT imaging of optic disc edema and optic atrophy. A: Spectral domain optical coherence tomography (SD-OCT) of right eyes injected with the mutant human ND4 packaged with the MTS scAAV revealed swelling of the optic nerve head (arrows) commencing at 1 month post injection. A focal increase in the thickness of the RGC and the inner plexiform layer (IPL) is apparent just to the right of the swollen optic nerve head. B: The control eye injected with scAAV-GFP showed the normal anatomy of the mouse optic nerve head. C: One year post injection, optic nerve head atrophy was apparent in the mutant ND4 injected eyes. D: The contralateral GFP injected control eyes maintained normal optic nerve head anatomy. E: One year post injection, focal thinning with loss of the inner retina was also apparent in an experimental eye, but this finding was not seen in any of the control eyes (F). RGC=retinal ganglion cell layer; IPL=inner plexiform layer.