Figure 4. The effects of heparanase and vascular endothelial growth factor (VEGF) protein expression levels on three group mice were as follows. A: It shows the expression of heparanase in the three groups by western blot. The band that represents the 50 kDa activated enzyme was more intense in Group B than in Group A, and the level was decreased by phosphomannopentaose sulfate (PI-88) treatment. B: It shows the expression of VEGF in the three groups by western blot. The band that represents the 50 kDa activated enzyme was more intense in Group B than in Group A, and the level was decreased by PI-88 treatment. C: The protein expression level of Group B increased compared with Group A. There was a significant difference in the heparanase expression between the groups (p<0.0001). D: The protein expression level in Group B increased compared with Group A. There was a significant difference in the VEGF expression between the groups (p<0.0001).