Figure 3. The effects of heparanase and vascular endothelial growth factor (VEGF) mRNA expression levels on oxygen-induced retinopathy (OIR) mice and normal mice were as follows. A: The mRNA expression level of heparanase increased 1.71 fold in Group B compared with Group A (p<0.0001) but decreased 2.18 fold in PI-88–treated mice compared with the group B (p<0.0001). There were significant differences in heparanase expression among the three groups (p<0.0001). B: The mRNA expression level of vascular endothelial growth factor (VEGF) increased 4.34 fold in Group B compared with Group A (p<0.0001) but decreased 2.00 fold in phosphomannopentaose sulfate (PI-88) treated mice compared with Group B (p<0.0001). There were significant differences in VEGF expression among the three groups (p<0.0001).