Figure 2. The effects of Immunohistochemistry staining for retina sections were accessed in this study. A-C: The retina sections stained for heparanase positive cells were show. A: It shows a normal mouse retina section on postnatal day 17 (P17). B: It displays the retina section in oxygen-induced retinopathy (OIR) mice. C: It shows PI-88 treatment of an OIR mouse retina. In all of the sections, the red arrow points to heparanase positive cells. D-F: The retina sections stained for vascular endothelial growth factor (VEGF) positive cells were show. D: It shows a normal mouse retina section on P17. E: It displays the retina section in OIR mice; F: It shows phosphomannopentaose sulfate (PI-88) treatment of an OIR mice retina. In all of the sections, the red arrow points to VEGF positive cells. G: The percentages of heparanase-positive cells in retina tissue by immunohistochemistry were as follows: The percentage of Group A was 32.00±7.00; the percentage of Group B was 51.33±1.53; the percentage Group C was 32.00±3.61. H: The percentages of VEGF-positive cells in retina tissue by immunohistochemistry were as follows: The percentage of Group A was 65.00±2.00. The percentage of Group B was 101.33±10.11; The percentage Group C was 19.00±2.65. The differences among groups were significant (p<0.0001).