Molecular Vision: Chen, Mol Vis 2012; 18:1629-1639. Table 3

Table 3. Genotype and allele distributions of rs1533428 at chromosome 2p16.3 in different age groups of the study populations

		Hong Kong cohort		Shantou cohort		Beijing cohort
Age group*	Genotype	POAG	Control	POAG	Control	POAG	Control	Combined cohort 1†	Combined cohort 2†
Any AAD	TT	34 (18.5)	39 (17.0)	16 (15.7)	26 (17.7)	19 (10.8)	28 (14.0)
	CT	95 (51.6)	98 (42.8)	55 (53.9)	60 (40.8)	91 (51.7)	85 (42.5)
	CC	55 (29.9)	92 (40.2)	31 (30.4)	61 (41.5)	66 (37.5)	87 (43.5)
p-value (dominant)		0.030		0.074		0.24		0.042	0.0033
OR (95% CI)		1.58 (1.04–2.38)		1.62 (0.95–2.77)		1.28 (0.85–1.94)		1.40 (1.01–1.94)	1.47 (1.14–1.90)
T allele		163 (44.3)	176 (38.4)	87 (42.6)	112 (38.1)	129 (36.6)	141 (35.3)
p-value		0.089		0.31		0.69
OR (95% CI)		1.27 (0.96–1.68)		1.21 (0.84–1.74)		1.06 (0.79–1.43)
AAD < 35 years	TT	0 (0.0)	-	5 (13.9)	-	5 (6.7)	-
	CT	10 (58.8)	-	19 (52.8)	-	38 (50.7)	-
	CC	7 (41.2)	-	12 (33.3)	-	32 (42.7)	-
p-value (dominant)		0.94		0.37		0.90		0.53	0.59
OR (95% CI)		0.96 (0.35–2.61)		1.42 (0.66–3.05)		1.03 (0.61–1.77)		1.15 (0.74–1.78)	1.12 (0.75–1.67)
T allele		10 (29.4)	-	29 (40.3)	-	48 (32.0)	-
p-value		0.30		0.73		0.48
OR (95% CI)		0.67 (0.31–1.43)		1.10 (0.65–1.86)		0.86 (0.58–1.29)
AAD 35 - 60 years	TT	12 (19.4)	-	4 (10.8)	-	11 (13.8)	-
	CT	24 (38.7)	-	22 (59.5)	-	42 (52.5)	-
	CC	26 (41.9)	-	11 (29.7)	-	27 (33.8)	-
p-value (dominant)		0.80		0.19		0.13		0.048	0.15
OR (95% CI)		0.93 (0.53–1.64)		1.68 (0.77–3.65)		1.51 (0.88–2.60)		1.56 (1.00–2.44)	1.29 (0.91–1.83)
T allele		48 (38.7)	-	30 (40.5)	-	64 (40.0)	-
p-value		0.95		0.70		0.29
OR (95% CI)		1.01 (0.67–1.52)		1.11 (0.66–1.86)		1.23 (0.84–1.79)
AAD > 60 years	TT	22 (21.0)	-	7 (24.1)	-	3 (14.3)	-
	CT	61 (58.1)	-	14 (48.3)	-	11 (52.4)	-
	CC	22 (21.0)	-	8 (27.6)	-	7 (33.3)	-
p-value (dominant)		0.00058		0.16		0.37		0.10	0.00025
OR (95% CI)		2.53 (1.48–4.34)		1.86 (0.77–4.48)		1.54 (0.60–3.98)		1.71 (0.90–3.25)	2.16 (1.43–3.26)
T allele		105 (50.0)	-	28 (48.3)	-	17 (40.5)	-
p-value		0.0049		0.15		0.50
OR (95% CI)		1.60 (1.15–2.23)		1.52 (0.86–2.67)		1.25 (0.65–2.39)

*Age groups were defined by age at diagnosis of the patients. The controls were not stratified, and was used as a reference for different age groups of patients. †Data from different study cohorts were combined using Mantel-Haenszel models with fixed effects. Combined cohort 1: combined Shantou and Beijing cohorts; Combined cohort 2: combined Hong Kong, Shantou and Beijing cohorts. AAD: age at diagnosis; OR: odds ratio; CI: confidence interval.