Table 4 of
Banerjee, Mol Vis 2012; 18:1548-1557. Table 4 of
Banerjee, Mol Vis 2012; 18:1548-1557.
Table 4. Clinical data of POAG patients harboring mutations in MYOC.
Patient ID (age at diagnosis in years) |
Mutation |
Subtype |
IOP (mm of Hg; RE, LE) |
Untreated IOP (mm of Hg; RE, LE) |
C:D ratio (RE, LE) |
Visual field changes |
Nerve Fiber Index (NFI; RE, LE) |
Prescribed medicine |
Other systemic disorders |
|---|---|---|---|---|---|---|---|---|---|
| GL1240 (64) | Arg33Lys | POAG (Familial) | 20, 21 | 20, 21 (post-operative) | 0.8, 0.8 | Double arcuate defect (BE) | N/A | Timolol | Cataract |
| GL634 (64) | Gln48His | POAG (Sporadic) | 11, 12 | 11, 12 (post-operative) | 0.8, 0.8 | Vision lost (RE), Gross constriction (LE) | N/A | Brimonidine | Hypertension |
| GL925 (56) | Gln48His | POAG (Familial) | 18,17 | 23,20.4 | 0.7, 0.6 | Superior Zone depression (RE), Superior & nasal defect (LE) | 63, 46 | Brimonidine | N/A |
| GL937 (58) | Gln48His | POAG (Familial) | 30, 25 | 30, 25 | N/A | Sup arcuate defect & inferior zone depression (RE) Double arcuate zone depression (LE) | 31, 42 | Latanoprost | Diabetes Mellitus, Hypertension |
| GL1000 (25) | Gln48His | JOAG (Familial) | 13.7, 37.7 | 13.7, 37.7 | 0.4, 0.9 | Minimum change in visual field (RE) Vision is PL positive (LE) | 27, 27 | Brimonidine +Timolol, Bimatoprost | N/A |
| GL883 (67) | R125SfsX158 | POAG (Familial) | 25, 21 | 32.5,27 | 0.9, 0.9 | Superior hemifield defect (RE) Superior arcuate defect (LE) | N/A | Brimonidine +Timolol | Cataract |
| GL1145 (43) | Thr256Met | POAG (Sporadic) | 21, 45 | 21, 45 | N/A | Enlarged blind spot (RE) Double arcuate defect (LE) | N/A | Latanoprost, Dorzolamide | Coronary artery disease |
| GL1129 (64) | D273DfsX344 | POAG (Familial) | 22.9, 37.9 | 22.9, 37.9 | N/A | Superior arcuate defect, (RE) Superior arcuate defect (LE) Enlarged blind spot (BE) | N/A | Latanoprost, Dorzolamide | Cataract |
| GL1208 (61) | Ser331Leu | POAG (Familial) | 22, 21 | 22, 21 | 0.5, 0.5 | Generalized depression (BE) | 22, 27 | Timolol, Betaxolol | Cataract, Bypass surgery, Diabetes Mellitus, Hypertension |
| GL796 (56) | Asp395Glu | POAG (Sporadic) | 24, 25 | 24, 25 | N/A | Generalized depression (BE) | N/A | N/A | Cataract |
| GL1104 (49) | Asp395Glu | POAG (Familial) | 21.9, 20.4 | 27.3,25.5 | 0.7, 0.6 | Enlarged blind spot (BE) | 42, 48 | Levobunolol | N/A |
| GL1117 (55) | Gln368Stop | POAG (Sporadic) | 41.3, 47 | 41.3, 47 | N/A | Generalized depression with double arcuate defect (RE) Superior arcuate zone depression (LE) | 17, 20 | Dorzolamide | N/A |