Table 2 of
Park, Mol Vis 2012; 18:1526-1539. Table 2 of
Park, Mol Vis 2012; 18:1526-1539.
Table 2. No significant associations identified between TGFβ2 SNPs and haplotypes and POAG.
| A | ||||||
|---|---|---|---|---|---|---|
| SNP ID | Allele | Phenotype | Case counts (%) | Control counts (%) | χ2 | Uncorrected p-value |
| rs10495098 | G | HTG | 297 (56.2) | 311 (56.8) | 0.03 | 0.8619 |
| G | OHT | 72 (65.5) | 311 (56.8) | 2.85 | 0.0912 | |
| G | HTG+OHT | 370 (57.8) | 311 (56.8) | 0.14 | 0.7125 | |
| rs17047682 | G | HTG | 39 (7.4) | 31 (5.7) | 1.32 | 0.2502 |
| G | OHT | 5 (4.5) | 31 (5.7) | 0.22 | 0.6399 | |
| G | HTG+OHT | 44 (6.9) | 31 (5.7) | 0.77 | 0.3819 | |
| rs2799097 | A | HTG | 69 (13.3) | 80 (15.0) | 0.67 | 0.4108 |
| A | OHT | 17 (16.0) | 80 (15.0) | 0.07 | 0.7934 | |
| A | HTG+OHT | 86 (13.7) | 80 (15.0) | 4.21 | 0.0601 | |
| rs17047703 | A | HTG | 140 (26.8) | 127 (23.2) | 1.89 | 0.1685 |
| A | OHT | 21 (19.1) | 127 (23.2) | 0.72 | 0.3956 | |
| A | HTG+OHT | 161 (25.5) | 127 (23.2) | 0.84 | 0.3591 | |
| rs17558745 | T | HTG | 191 (36.6) | 169 (31.2) | 3.47 | 0.0623 |
| T | OHT | 30 (28.0) | 169 (31.2) | 0.01 | 0.9134 | |
| T | HTG+OHT | 221 (35.1) | 169 (31.2) | 1.99 | 0.1579 | |
| rs2796817 | G | HTG | 70 (13.2) | 83 (15.1) | 0.78 | 0.3749 |
| G | OHT | 19 (17.3) | 83 (15.1) | 0.33 | 0.5633 | |
| G | HTG+OHT | 89 (13.9) | 83 (15.1) | 0.34 | 0.5623 | |
| rs3892225 | G | HTG | 119 (22.5) | 106 (19.3) | 1.74 | 0.1873 |
| G | OHT | 20 (18.2) | 106 (19.3) | 0.07 | 0.7904 | |
| G | HTG+OHT | 139 (21.8) | 106 (19.3) | 1.14 | 0.2855 | |
| rs2009112 | C | HTG | 215 (40.6) | 222 (40.4) | 0.01 | 0.946 |
| C | OHT | 42 (38.2) | 222 (40.4) | 0.18 | 0.6698 | |
| C | HTG+OHT | 257 (40.2) | 222 (40.4) | 0.01 | 0.9420 | |
| rs10482751 | C | HTG | 145 (27.6) | 153 (27.8) | 0.01 | 0.9265 |
| C | OHT | 30 (27.3) | 153 (27.8) | 0.01 | 0.9071 | |
| C | HTG+OHT | 175 (27.5) | 153 (27.8) | 0.01 | 0.9076 | |
| rs2027566 | C | HTG | 167 (31.5) | 172 (31.4) | 0.00 | 0.9654 |
| C | OHT | 35 (31.8) | 172 (31.4) | 0.01 | 0.9292 | |
| C | HTG+OHT | 202 (31.6) | 172 (31.4) | 0.00 | 0.9482 | |
| rs2027567 | G | HTG | 116 (22.1) | 124 (22.5) | 0.04 | 0.8463 |
| G | OHT | 22 (20.0) | 124 (22.5) | 0.35 | 0.5571 | |
| G | HTG+OHT | 138 (21.7) | 124 (22.5) | 0.12 | 0.7258 | |
| rs2796814 | G | HTG | 132 (25.1) | 118 (21.6) | 1.82 | 0.1776 |
| G | OHT | 26 (23.6) | 118 (21.6) | 0.22 | 0.6398 | |
| G | HTG+OHT | 158 (24.8) | 118 (21.6) | 1.71 | 0.1905 | |
| rs947712 | T | HTG | 185 (35.6) | 191 (35.1) | 0.03 | 0.8735 |
| T | OHT | 41 (37.3) | 191 (35.1) | 0.19 | 0.6655 | |
| T | HTG+OHT | 226 (35.9) | 191 (35.1) | 0.07 | 0.7854 | |
| rs10779329 | C | HTG | 124 (23.6) | 119 (21.7) | 0.53 | 0.4667 |
| C | OHT | 31 (28.2) | 119 (21.7) | 2.18 | 0.1401 | |
| C | HTG+OHT | 155 (24.4) | 119 (21.7) | 1.17 | 0.2800 | |
| rs1317681 | A | HTG | 84 (15.9) | 89 (16.4) | 0.04 | 0.8409 |
| A | OHT | 20 (18.5) | 89 (16.4) | 0.30 | 0.5830 | |
| A | HTG+OHT | 104 (16.4) | 89 (16.4) | 0.00 | 0.9970 | |
| rs2796821 | T | HTG | 147 (27.8) | 144 (26.2) | 0.38 | 0.5396 |
| T | OHT | 33 (30.0) | 144 (26,2) | 0.68 | 0.4093 | |
| T | HTG+OHT | 180 (28.2) | 144 (26.2) | 0.61 | 0.4331 | |
| rs1342586 | C | HTG | 106 (20.0) | 125 (22.8) | 1.26 | 0.2609 |
| C | OHT | 19 (17.3) | 125 (22.8) | 1.64 | 0.1999 | |
| C | HTG+OHT | 125 (19.5) | 125 (22.8) | 1.91 | 0.1669 | |
| rs2798631 | G | HTG | 255 (48.7) | 267 (48.9) | 0.01 | 0.9382 |
| G | OHT | 55 (50.0) | 267 (48.9) | 0.04 | 0.8334 | |
| G | HTG+OHT | 310 (48.9) | 267 (48.9) | 0.00 | 0.9986 | |
| rs1473526 | C | HTG | 138 (26.1) | 150 (27.3) | 0.18 | 0.6734 |
| C | OHT | 26 (23.6) | 150 (27.3) | 0.62 | 0.4311 | |
| C | HTG+OHT | 64 (25.7) | 150 (27.3) | 0.37 | 0.5413 | |
| B | ||||||
| Block | Haplotype | All subjects (%) | Case (%) | Control (%) | χ2 | p-value |
| 1 | ||||||
| (tSNPs 1 to 4) | GAGC | 42.2 | 42.9 | 41.6 | 0.19 | 0.6657 |
| TAGC | 18.8 | 17.3 | 20.2 | 1.56 | 0.2112 | |
| TAGA | 18.3 | 19.1 | 17.5 | 0.49 | 0.4841 | |
| GAAC | 14.2 | 13.4 | 15.1 | 0.67 | 0.4123 | |
| TGGA | 6.5 | 7.4 | 5.6 | 1.39 | 0.2379 | |
| 2 | ||||||
| (tSNPs 8 to 11) | TCAA | 40.1 | 40.1 | 40.1 | 0.00 | 0.9891 |
| CCAA | 28.4 | 28.3 | 28.5 | 0.01 | 0.9386 | |
| CTCG | 21.5 | 21.2 | 21.9 | 0.08 | 0.7746 | |
| CTCA | 6.0 | 6.3 | 5.7 | 0.20 | 0.6592 | |
| CCCA | 3.0 | 2.9 | 3.2 | 0.10 | 0.7473 | |
| 3 | ||||||
| (tSNPs 14 to 15) | TG | 77.4 | 76.5 | 78.3 | 0.47 | 0.4950 |
| CA | 16.2 | 16.0 | 16.5 | 0.05 | 0.8175 | |
| CG | 6.3 | 7.5 | 5.2 | 2.32 | 0.1280 | |
| 4 | ||||||
| (tSNPs 17 to 19) | CAT | 51.1 | 51.1 | 51.1 | 0.00 | 0.9927 |
| CGT | 22.1 | 22.7 | 21.5 | 0.21 | 0.6462 | |
| TGC | 21.2 | 19.8 | 22.6 | 1.28 | 0.2581 | |
| CGC | 5.5 | 6.2 | 4.7 | 1.16 | 0.2809 | |
| C | ||||||
| Block | Haplotype | All subjects (%) | Case (%) | Control (%) | χ2 | p-Value |
| 1 | ||||||
| (tSNPs 1 to 4) | GAGC | 42.9 | 44.0 | 41.6 | 0.70 | 0.4035 |
| TAGC | 18.6 | 17.1 | 20.3 | 1.92 | 0.1664 | |
| TAGA | 17.8 | 18.1 | 17.4 | 0.10 | 0.7500 | |
| GAAC | 14.3 | 13.7 | 15.1 | 0.48 | 0.4866 | |
| TGGA | 6.3 | 6.9 | 5.6 | 0.82 | 0.3659 | |
| 2 | ||||||
| (tSNPs 8 to 11) | TCAA | 39.8 | 39.6 | 40.1 | 0.03 | 0.8680 |
| CCAA | 28.7 | 28.8 | 28.5 | 0.01 | 0.9220 | |
| CTCG | 21.4 | 20.9 | 21.9 | 0.15 | 0.6992 | |
| CTCA | 6.0 | 6.3 | 5.7 | 0.22 | 0.6401 | |
| CCCA | 3.2 | 3.1 | 3.2 | 0.00 | 0.9491 | |
| 3 | ||||||
| (tSNPs 14 to 15) | TG | 76.9 | 75.7 | 78.3 | 1.08 | 0.2979 |
| CA | 16.4 | 16.4 | 16.5 | 0.00 | 0.9485 | |
| CG | 6.7 | 7.9 | 5.2 | 3.44 | 0.0636 | |
| 4 | ||||||
| (tSNPs 17 to 19) | CAT | 51.0 | 50.9 | 51.1 | 0.01 | 0.9415 |
| CGT | 22.5 | 23.3 | 21.5 | 0.54 | 0.4606 | |
| TGC | 20.9 | 19.4 | 22.6 | 1.89 | 0.1691 | |
| CGC | 5.6 | 6.3 | 4.7 | 1.29 | 0.2556 | |