Figure 3. Heat map analysis revealed that the 5,666 genes exhibiting statistically significant changes in expression level (false discovery rate [FDR] α<0.05) could be clustered into one of four groups. Genes from the Jak/STAT, Wnt, and Notch pathways are shown relative to positioning in the relevant clusters, along with arrows next to each gene name indicating if the gene is upregulated or downregulated. Asterisk (*) indicates significant fold change (|fold change|>2).