Figure 6. Effect of fumonisin B1 on the palmitate-induced IL-6 and MCP-1 secretion from orbital fibroblasts. Orbital fibroblasts were pretreated with fuminosin B1 (10 μM) for 1 h, followed by treatment with palmitate (200 μM) for 24 h. Concentrations of IL-6 (A) and MCP-1 (B) were determined by ELISA. Data are presented as the mean±SD of three replicate culture wells from a representative experiment. Similar results were observed in three independent experiments using orbital fibroblasts from #1 patient with TAO (Table 1). * p<0.05.