Figure 5. Higher levels of IL-6 and MCP-1 secreted from orbital fibroblasts than from dermal fibroblasts under basal conditions and in response to palmitate. Orbital and dermal fibroblasts were treated with palmitate for 24 h. Concentrations of IL-6 (A) and MCP-1 (B) were determined by ELISA. Data are presented as the mean±SD of three replicate culture wells from a representative experiment. Similar results were observed in three independent experiments using orbital fibroblasts from #1 patient with TAO (Table 1). * p<0.05 versus cells treated with same concentration of palmitate.