Figure 7. Established hypertension
alone or in combination with diabetes stimulates JNK stress
pathway and impairs the survival Akt pathway. A:
Representative image for western blot analysis of retinal
phosphorylated-Jun N-terminal kinase (pJNK) protein expression
in the established stage of spontaneous hypertensive rats (SHR)
and diabetic spontaneous hypertensive rats (SHR+D) compared to
control wistar group (W). B: Statistical analysis showed
that activation of pJNK was higher by threefold in the SHR group
that was increased to 8.35 fold in the combined SHR+D group
relative to the control W group (n=3, *p<0.05). C:
Representative image for western blot analysis of retinal
phosphorylated-AKt (AKt) protein expression in the established
stage of SHR and SHR+D compared to W. D: Statistical
analysis showing that activation of pAkt tends to be inhibited
by 0.3 fold in the SHR group and 0.4 fold in the combined SHR+D
group relative to the control W group (n=3, p=0.19 and 0.26,
respectively).