Table 5 of Mitra, Mol Vis 2012; 18:1361-1378.

Table 5. Genes down-regulated in Y79 cell grown with microparticles (3-D) compared to those without microparticles (2-D).

Gene name Protein name Fold change P value function
APAF-1 Homo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 3, mRNA [NM_181861] −1.9839 0.0012 Apaf-1, a cell-death effector that acts with cytochrome c and caspase-9 to mediate p53-dependent apoptosis
PIK3R3 Homo sapiens phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) (PIK3R3), mRNA [NM_003629] −1.644 0.0008 Pro-apoptosis.
SFRS1 Homo sapiens splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) (SFRS1), transcript variant 1, mRNA [NM_006924] −1.0263 0.0001 Pro-cell death
FKBP14 Homo sapiens FK506 binding protein 14, 22 kDa (FKBP14), mRNA [NM_017946] −0.9243 0.0099 Pro-apoptosis
PPP1R1B Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) (PPP1R1B), transcript variant 1, mRNA [NM_032192] −1.5266 0.0007 Pro-apoptosis
ANXA5 Homo sapiens annexin A5 (ANXA5), mRNA [NM_001154] −3.7394 0.0002 Pro- apoptosis
TCF12 Homo sapiens transcription factor 12 (HTF4, helix–loop–helix transcription factors 4) (TCF12), transcript variant 4, mRNA [NM_207038] −1.0896 0.0028 Pro apoptosis
PDCD2 Homo sapiens programmed cell death 2 (PDCD2), transcript variant 1, mRNA [NM_002598] −1.3256 0.0011 Pro apoptosis
ACTN4 Homo sapiens actinin, alpha 4 (ACTN4), mRNA [NM_004924] −1.3227 0 Pro apoptis
MAPK6 Homo sapiens mitogen-activated protein kinase 6 (MAPK6), mRNA [NM_002748] −1.1824 0.0236 Pro apoptosis
EIF5A2 Homo sapiens eukaryotic translation initiation factor 5A2 (EIF5A2), mRNA [NM_020390] −1.4533 0.0001 Pro apoptosis
MAP3K13 Homo sapiens mitogen-activated protein kinase kinase kinase 13 (MAP3K13), mRNA [NM_004721] −1.4791 0.0138 Pro apoptosis
HIST2H2BE Homo sapiens histone cluster 2, H2be (HIST2H2BE), mRNA −1.8046 0.001 Pro apoptosis
HIST1H1C Homo sapiens histone cluster 1, H1c (HIST1H1C), mRNA [NM_005319] −1.1425 0.0002 Pro apoptosis
PDCD6IP Homo sapiens programmed cell death 6 interacting protein (PDCD6IP), mRNA [NM_013374] −1.2727 0.0073 Pro apoptosis
CFL1 Homo sapiens cofilin 1 (non-muscle) (CFL1), mRNA [NM_005507] −1.1578 0.0068 Pro apoptosis
EIF2AK3 Homo sapiens eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3), mRNA [NM_004836] −1.502 0.0013 Proapoptosis
BUB3 Homo sapiens mRNA for BUB3 budding uninhibited by benzimidazoles 3 isoform a variant, clone: hg01710. [AK226060] −1.7701 0.003 Pro apoptosis
ARHGAP21 Homo sapiens Rho GTPase activating protein 21 (ARHGAP21), mRNA [NM_020824] −1.4986 0.0001 Anti metastasis
KRT17 Homo sapiens keratin 17 (KRT17), mRNA [NM_000422] −1.5924 0.0057 Anti metastasis
CD46 Homo sapiens CD46 molecule, complement regulatory protein (CD46), transcript variant a, mRNA [NM_002389] −1.3955 0.0004 Anti metastasis
SERPINH1 Homo sapiens serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) (SERPINH1), mRNA [NM_001235] −1.1452 0 Anti-metastasis
BRMS1L Homo sapiens breast cancer metastasis-suppressor 1-like (BRMS1L), mRNA [NM_032352] −1.0558 0 Anti-metastasis
PANK3 Homo sapiens pantothenate kinase 3 (PANK3), mRNA [NM_024594] −0.9712 0.0019 Anti-metastasis
LGALS7 Homo sapiens lectin, galactoside-binding, soluble, 7 (galectin 7) (LGALS7), mRNA [NM_002307] −1.0622 0.0002 Anti-metastasis
STK4 Homo sapiens serine/threonine kinase 4, mRNA (cDNA clone IMAGE:3950315), complete cds. [BC005231] −0.9328 0.0002 Tumor supression
PARP9 Homo sapiens poly (ADP-ribose) polymerase family, member 9 (PARP9), mRNA [NM_031458] −1.4829 0.038 Tumor supression
CDKN1A Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant −2.0045 0.0027 Tumor supression
CDKN1C −4.2038 0.0002 Tumor supression
CDKN2C Homo sapiens cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (CDKN2C), transcript variant 1, mRNA [NM_001262] −2.9462 0 Tumor supression
CDKN2A Homo sapiens cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 3, mRNA [NM_058197] −2.2861 0.0002 Tumor supression
KREMEN1 Homo sapiens kringle containing transmembrane protein 1 (KREMEN1), transcript variant 1, mRNA [NM_153379] −1.3621 0.0034 Tumor supression
SASH1 Homo sapiens SAM and SH3 domain containing 1 (SASH1), mRNA [NM_015278] −4.8233 0 Tumor supression
RRM2 Homo sapiens ribonucleotide reductase M2 polypeptide (RRM2), mRNA [NM_001034] −1.309 0.0032 angiogenesis