Table 5 of
Mitra, Mol Vis 2012; 18:1361-1378. Table 5 of
Mitra, Mol Vis 2012; 18:1361-1378.
Table 5. Genes down-regulated in Y79 cell grown with microparticles (3-D) compared to those without microparticles (2-D).
| Gene name | Protein name | Fold change | P value | function |
|---|---|---|---|---|
| APAF-1 | Homo sapiens apoptotic peptidase activating factor 1 (APAF1), transcript variant 3, mRNA [NM_181861] | −1.9839 | 0.0012 | Apaf-1, a cell-death effector that acts with cytochrome c and caspase-9 to mediate p53-dependent apoptosis |
| PIK3R3 | Homo sapiens phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) (PIK3R3), mRNA [NM_003629] | −1.644 | 0.0008 | Pro-apoptosis. |
| SFRS1 | Homo sapiens splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) (SFRS1), transcript variant 1, mRNA [NM_006924] | −1.0263 | 0.0001 | Pro-cell death |
| FKBP14 | Homo sapiens FK506 binding protein 14, 22 kDa (FKBP14), mRNA [NM_017946] | −0.9243 | 0.0099 | Pro-apoptosis |
| PPP1R1B | Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32) (PPP1R1B), transcript variant 1, mRNA [NM_032192] | −1.5266 | 0.0007 | Pro-apoptosis |
| ANXA5 | Homo sapiens annexin A5 (ANXA5), mRNA [NM_001154] | −3.7394 | 0.0002 | Pro- apoptosis |
| TCF12 | Homo sapiens transcription factor 12 (HTF4, helix–loop–helix transcription factors 4) (TCF12), transcript variant 4, mRNA [NM_207038] | −1.0896 | 0.0028 | Pro apoptosis |
| PDCD2 | Homo sapiens programmed cell death 2 (PDCD2), transcript variant 1, mRNA [NM_002598] | −1.3256 | 0.0011 | Pro apoptosis |
| ACTN4 | Homo sapiens actinin, alpha 4 (ACTN4), mRNA [NM_004924] | −1.3227 | 0 | Pro apoptis |
| MAPK6 | Homo sapiens mitogen-activated protein kinase 6 (MAPK6), mRNA [NM_002748] | −1.1824 | 0.0236 | Pro apoptosis |
| EIF5A2 | Homo sapiens eukaryotic translation initiation factor 5A2 (EIF5A2), mRNA [NM_020390] | −1.4533 | 0.0001 | Pro apoptosis |
| MAP3K13 | Homo sapiens mitogen-activated protein kinase kinase kinase 13 (MAP3K13), mRNA [NM_004721] | −1.4791 | 0.0138 | Pro apoptosis |
| HIST2H2BE | Homo sapiens histone cluster 2, H2be (HIST2H2BE), mRNA | −1.8046 | 0.001 | Pro apoptosis |
| HIST1H1C | Homo sapiens histone cluster 1, H1c (HIST1H1C), mRNA [NM_005319] | −1.1425 | 0.0002 | Pro apoptosis |
| PDCD6IP | Homo sapiens programmed cell death 6 interacting protein (PDCD6IP), mRNA [NM_013374] | −1.2727 | 0.0073 | Pro apoptosis |
| CFL1 | Homo sapiens cofilin 1 (non-muscle) (CFL1), mRNA [NM_005507] | −1.1578 | 0.0068 | Pro apoptosis |
| EIF2AK3 | Homo sapiens eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3), mRNA [NM_004836] | −1.502 | 0.0013 | Proapoptosis |
| BUB3 | Homo sapiens mRNA for BUB3 budding uninhibited by benzimidazoles 3 isoform a variant, clone: hg01710. [AK226060] | −1.7701 | 0.003 | Pro apoptosis |
| ARHGAP21 | Homo sapiens Rho GTPase activating protein 21 (ARHGAP21), mRNA [NM_020824] | −1.4986 | 0.0001 | Anti metastasis |
| KRT17 | Homo sapiens keratin 17 (KRT17), mRNA [NM_000422] | −1.5924 | 0.0057 | Anti metastasis |
| CD46 | Homo sapiens CD46 molecule, complement regulatory protein (CD46), transcript variant a, mRNA [NM_002389] | −1.3955 | 0.0004 | Anti metastasis |
| SERPINH1 | Homo sapiens serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) (SERPINH1), mRNA [NM_001235] | −1.1452 | 0 | Anti-metastasis |
| BRMS1L | Homo sapiens breast cancer metastasis-suppressor 1-like (BRMS1L), mRNA [NM_032352] | −1.0558 | 0 | Anti-metastasis |
| PANK3 | Homo sapiens pantothenate kinase 3 (PANK3), mRNA [NM_024594] | −0.9712 | 0.0019 | Anti-metastasis |
| LGALS7 | Homo sapiens lectin, galactoside-binding, soluble, 7 (galectin 7) (LGALS7), mRNA [NM_002307] | −1.0622 | 0.0002 | Anti-metastasis |
| STK4 | Homo sapiens serine/threonine kinase 4, mRNA (cDNA clone IMAGE:3950315), complete cds. [BC005231] | −0.9328 | 0.0002 | Tumor supression |
| PARP9 | Homo sapiens poly (ADP-ribose) polymerase family, member 9 (PARP9), mRNA [NM_031458] | −1.4829 | 0.038 | Tumor supression |
| CDKN1A | Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant | −2.0045 | 0.0027 | Tumor supression |
| CDKN1C | −4.2038 | 0.0002 | Tumor supression | |
| CDKN2C | Homo sapiens cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) (CDKN2C), transcript variant 1, mRNA [NM_001262] | −2.9462 | 0 | Tumor supression |
| CDKN2A | Homo sapiens cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 3, mRNA [NM_058197] | −2.2861 | 0.0002 | Tumor supression |
| KREMEN1 | Homo sapiens kringle containing transmembrane protein 1 (KREMEN1), transcript variant 1, mRNA [NM_153379] | −1.3621 | 0.0034 | Tumor supression |
| SASH1 | Homo sapiens SAM and SH3 domain containing 1 (SASH1), mRNA [NM_015278] | −4.8233 | 0 | Tumor supression |
| RRM2 | Homo sapiens ribonucleotide reductase M2 polypeptide (RRM2), mRNA [NM_001034] | −1.309 | 0.0032 | angiogenesis |