Figure 7. This figure shows the anti-proliferative effect of drug loaded nanoparticles on Y79 cells cultures in Two-dimensional (2-D) or three dimensional (3-D) patterns. A: Y79 cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.001) to native carboplatin when compared to Y79 cells cultured without microparticles (2-D). B: Y79 cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.0001) to Carboplatin loaded nanoparticles when compared to Y79 cells cultured without microparticles (2-D). C: Y79 cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.001) to native etoposide when compared to Y79 cells cultured without microparticles (2-D). D: Y79 cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.001) to etoposide-loaded Np when compared to Y79 cells cultured without microparticles (2-D). E: Y79 cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.001) to native doxorubicin when compared to Y79 cells cultured without microparticles (2-D). F: Y79 cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.001) to doxorubicin loaded nanoparticles when compared to Y79 cells cultured without microparticles (2-D). G: Fresh retinoblastoma tumor cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.001) to native carboplatin when compared to Y79 cells cultured without microparticles (2-D). H: Fresh retinoblastoma tumor cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.0001) to native etoposide when compared to Y79 cells cultured without microparticles (2-D). I: Fresh retinoblastoma tumor cells co-cultured with microparticles (3-D) shows decreased sensitivity (p<0.001) to native doxorubicin when compared to Y79 cells cultured without microparticles (2-D). Error bars represent standard deviation obtained from triplicates.