Figure 4 of Blom, Mol Vis 2012; 18:1339-1353.


Figure 4. Immunocytochemical localization of the adrenomedullin (ADM) receptor calcitonin receptor like receptor (CRLR) and receptor activity modifying protein (RAMP2). A: The ADM receptor CRLR-like immunoreactivity (LI) was localized near the outer segments of photoreceptors (diagonal arrow), in faint somata in the outer nuclear layer (ONL; horizontal arrow), in puncta in the outer plexiform layer (OPL; asterisk), in select cell somata in the inner nuclear layer (INL; arrowhead), in delicate puncta in the inner plexiform layer (IPL), and in numerous somata in the ganglion cell layer (GCL; vertical arrow). B: RAMP2-LI was localized near the photoreceptor outer segments (diagonal arrow), in somata in the ONL (horizontal arrow), and in somata in the INL (arrowhead) and GCL (vertical arrow). Scale bars=20 µm. C: western blot of mouse retinal homogenate probed with the same CRLR and RAMP2 antisera used for immunocytochemistry. Both antisera recognized single proteins with the correct molecular weights.