Figure 4. Methylation percentages of cytosine-phosphate-guanine (CpG) sites in the collagen type Iα1 promoter region in scleras of monocular deprivation and control eyes after four weeks of monocular deprivation. Numbers in parentheses on the x-axis are the locations of the cytosine-phosphate-guanine (CpG) sites. Methylation percentages at sites 1, 3, 9, 14, 18, and 19 were significantly greater in monocular deprivation–treated (MD-T) eyes than age-matched normal control (NC₅₁) eyes. MD-T: monocular deprivation-treated eyes, MD-C: contralateral control eyes. *, p<0.05, **, p<0.01.