Figure 5. Intravitreal injection of a HIF-1α inhibitor in Cited2^CKO mice. Six-eight weeks old mice were received intravitreal injection of Topotecan (TPT). Fifty or 100 μg of TPT was injected into the left eye of Cited2^CKO mouse. Saline was injected into right eye as a negative control. Representative pictures are shown for 50 μg and 100 μg of TPT injection.