Figure 4. Le-Cre mediated deletion of Cited2 and VEGF and phenotypic rescue by VEGF deletion. The expression level of Cited2 was decreased in Cited2^fl/fl;VEGF^fl/fl;Le-Cre⁺ mouse lens compared to the control (n=3, *p<0.05). B: Relative VEGF mRNA expression was decreased in Cited2^fl/fl;VEGF^fl/fl;Le-Cre⁺ mouse lens compared to Cited2^CKO. C: Morphological changes were similar between Cited2^CKO and Cited2^fl/fl;VEGF^fl/fl;Le-Cre⁺ by gross examination or under dissecting microscope (upper panel). The insets represent higher magnification of the areas indicated by arrows.