Table 4 of
Gibson, Mol Vis 2012; 18:1083-1092. Table 4 of
Gibson, Mol Vis 2012; 18:1083-1092.
Table 4. Evidence for published POAG risk and quantitative trait genes.
| Gene (region) | phenotype | Published SNP | Published discovery p-value | Reference | P-values in our discovery data (where SNP is available) |
|---|---|---|---|---|---|
| CAV1/CAV2 | POAG | rs4236601 | 5.0×10−10 | [9] | Not in our data |
| TMCO1 | POAG | rs7518099 | 4.7×10−10 | [11] | 8.9×10−4 |
| SRBD1 | POAG/NTG | rs3213787 | 2.5×10−9 | [12,26] | not in our data. rs2082876 p=0.0005 POAG, p=4.28×10-5 HTG, see results section. |
| CDKN2B | POAG | rs10120688 | 1.4×10−8 | [11] | 1.2×10-5 *evidence also in nearby MTAP |
| SIX1 | VCDR/POAG | rs10483727 | 2.93×10−10 | [15] | 0.3 CDR/0.076 POAG |
| ELOVL5 | POAG/NTG | rs735860 | 4.14×10−6 | [12] | 0.6 POAG/0.7 NTG |
| ATOH7 | Disc area | rs3858145 rs1900004 rs690037 | 6.2×10−10 1.3×10−10 1.5×10−7 | [14] | We have not tested disc area rs1900004 p=0.07 for CDR. The others not in our data |
| CDC7/TGFBR3 | Disc area | rs1192415 | 7.57×10−17 (meta p-value) | [13] | not in our data |
| CARD10 | Disc area | rs9607469 | 2.73×10−12 (meta p-value) | [13] | 0.79 for CDR |
| ZNF469 | CCT | rs12447690 | 2.87×10−8 | [16] | not in our data |
| COL5A1 | CCT | rs1536482 | 7.1×10−8 | [17] | not in our data |
| AKAP13 | CCT | rs6496932 | 1.4×10−8 | [17] | 0.23 |
| COL8A2 | CCT | rs274754 | 0.018 | [27] | not in our data |
| AVGR8 | CCT | rs1034200 | 3.5×10−9 | [17] | not in our data |