Table 3 of Gibson, Mol Vis 2012; 18:1083-1092.

Phenotype |
SNP |
Location |
Nearest gene(s) |
Frequency of allele 1in discovery cases, controls, (allele2)/Qtrait mean direction |
Frequency of allele 1in replication cases, controls, (allele2)/Qtrait mean direction |
Discovery p-value |
Replication p-value |
---|---|---|---|---|---|---|---|

Most significant GWAS region |
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POAG | rs11961171 | chr6:11384014 | NEDD9 |
A=0.1158, 0.05332 (G) | A=0.04762, 0.06 (G) | 8.55E-13 | 0.5974 |

POAG | rs967473 | chr6:11437409 | NEDD9 |
A=0.1899, 0.1407 (G) | A=0.1382, 0.15 (G) | 0.000167 | 0.7538 |

POAG | rs9366868 | chr6:11811486 | C6orf105 |
A=0.3329, 0.4098 (G) | A=0.4041, 0.49 (G) | 2.59E-05 | 0.1074 |

Significant at replication |
|||||||

avCCT | rs17128941 | chr14:92754850 | C14orf130
(UBR7) |
T->C increasing CCT | T->C increasing CCT | 5.52E-06 | 0.02743 |

avCDR | rs4385494 | chr8:136919236 | KHDRBS3 |
T->G increasing CDR | T->G increasing CDR | 4.51E-05 | 0.02937 |

HTG | rs4237260 | chr9:75931236 | RORB |
C=0.3199, 0.233 (G) | C=0.206, 0.35 (G) | 4.98E-07 | 0.001949* |

NTG | rs7785999 | chr7:32427787 | PDE1C,
LSM5 |
A=0.2692, 0.1467 (C) | A=0.09483, 0.1939 (C) | 9.22E-05 | 0.02932* |