Molecular Vision: Khandelwal, Mol Vis 2012; 18:1055-1067. Table 7

Table 7. Influence of DHT on the expression of gene ontologies in human meibomian gland epithelial cells.

Ontology	DHT Genes ↑	Plac Genes ↑	DHT z-score	Plac z-score
Biologic Process
programmed cell death	136	143	5.18	5.09
oxidation-reduction process	95	61	4.85	−0.42
protein metabolic process	280	278	4.35	2.85
purine ribonucleotide metabolic process	50	37	3.8	0.87
nerve growth factor receptor signaling pathway	28	22	3.38	1.44
response to hormone stimulus	61	48	3.36	0.7
regulation of signaling	132	106	3.14	−0.45
tissue development	80	69	2.58	0.46
cell cycle	75	202	−0.65	13.58
M phase	14	107	-3.29	13.34
DNA metabolic process	38	118	−0.87	11.17
organelle fission	12	81	-2.41	11.94
RNA processing	39	111	−0.49	10.47
angiogenesis	21	30	1.05	2.95
immune system process	99	122	0.86	2.66
innate immune response	27	41	−0.08	2.28
blood vessel development	30	35	1.49	2.15
regulation of cellular biosynthetic process	139	148	-2.24	-2.39
regulation of transcription	111	119	-2.26	-2.33
neurologic system process	59	33	-3.68	-7.15
Molecular Function
protein binding	572	707	6.41	13.12
hydrogen ion transmembrane transporter activity	21	3	5.82	−1.58
oxidoreductase activity, acting on CH-OH group of donors	23	9	5.47	0.17
catalytic activity	423	403	5.11	2.27
translation factor activity, nucleic acid binding	16	8	4.47	0.82
peptidase activity	55	36	3.01	−0.63
RNA binding	61	127	1.12	10.03
nucleotide binding	164	243	1.32	7.58
ATPase activity	31	42	1.61	3.59
helicase activity	7	20	−0.89	3.2
ion channel activity	14	12	-2.51	-3.15
DNA binding	115	149	-2.82	−0.43
zinc ion binding	121	99	−0.68	-3.47
transporter activity	82	50	0.41	-3.94
transmembrane receptor activity	33	26	-5.76	-6.98
Cellular Component
vacuole	56	20	7.82	−0.56
lysosome	45	20	6.54	0.19
intracellular organelle	721	852	5.76	11.82
organelle membrane	191	152	5.26	0.86
endoplasmic reticulum	109	76	4.97	0.28
peroxisome	19	4	4.85	−1.23
nuclear part	165	335	−0.05	13.77
organelle lumen	195	344	1.62	13.26
ribonucleoprotein complex	37	104	0.52	12.01
chromosome	27	97	−1.62	10.08
spindle	9	47	−0.99	9.87
extracellular space	37	57	-2.23	0.31
cell junction	38	28	−0.19	−2.17
extracellular region	98	105	-3.36	-3.26
intrinsic to membrane	307	246	-2.55	−7.7

Designated ontologies were selected after the analyses of log-transformed data. Criteria for inclusion were an ontology containing ≥8 genes and having a z-score >2.0 or <-2.0. High and low values for the placebo (Plac) and DHT groups in specific ontologies are highlighted in bold print. Androgen administration also stimulated over 25 different ontologies related to lipid biosynthesis, homeostasis, transport and binding, as previously shown [2].