Table 2 of
Khandelwal, Mol Vis 2012; 18:1055-1067. Table 2 of
Khandelwal, Mol Vis 2012; 18:1055-1067.
Table 2. Effect of DHT on gene expression ratios in immortalized human meibomian gland epithelial cells.
| Accession # | Gene | Ratio | p value | Ontology |
|---|---|---|---|---|
| DHT>Placebo | ||||
| NM_001001552 | LEM domain containing 1 | 10.1 | 0.00000 | nuclear envelope |
| NM_032563 | Late cornified envelope 3D | 4.5 | 0.00024 | keratinization |
| NM_152565 | ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d2 | 3.7 | 0.00048 | ion transport |
| NM_021244 | Ras-related GTP binding D | 3.5 | 0.00010 | positive regulation of TOR signaling cascade |
| NM_001031615 | Aldehyde dehydrogenase 3 family, member B2 | 3.0 | 0.00004 | alcohol metabolic process |
| NM_000435 | Notch homolog 3 | 2.9 | 0.00015 | regulation of transcription, DNA-dependent |
| NM_005218 | Defensin, β1 | 2.6 | 0.00001 | chemotaxis |
| NM_001003679 | Leptin receptor | 2.5 | 0.00553 | energy reserve metabolic process |
| NM_001047 | Steroid-5α-reductase, α polypeptide 1 | 1.9 | 0.00097 | androgen biosynthetic process |
| NM_005063 | Stearoyl-CoA desaturase | 1.7 | 0.00039 | fatty acid biosynthetic process |
| NM_002015 | Forkhead box O1 | 1.6 | 0.00006 | blood vessel development |
| Placebo>DHT | ||||
| NM_181800 | Ubiquitin-conjugating enzyme E2C | 24.4 | 0.00000 | cell cycle checkpoint |
| NM_001067 | Topoisomerase (DNA) II α 170 kDa | 16.7 | 0.00000 | resolution of meiotic recombination intermediates |
| NM_018454 | Nucleolar and spindle associated protein 1 | 15.6 | 0.00006 | mitotic sister chromatid segregation |
| NM_001255 | Cell division cycle 20 homolog | 13.4 | 0.00001 | cell cycle checkpoint |
| NM_001786 | Cyclin-dependent kinase 1 | 12.3 | 0.00000 | cell cycle checkpoint |
| NM_001168 | Baculoviral IAP repeat-containing 5 | 10.2 | 0.00000 | G2/M transition of mitotic cell cycle |
| NM_004701 | Cyclin B2 | 9.5 | 0.00002 | cell cycle checkpoint |
| NM_002263 | Kinesin family member C1 | 9.0 | 0.00000 | mitotic sister chromatid segregation |
| NM_002994 | Chemokine (C-X-C motif) ligand 5 | 8.9 | 0.00019 | chemotaxis |
| NM_003246 | Thrombospondin 1 | 4.7 | 0.00001 | activation of MAPK activity |
| NM_002727 | Serglycin | 2.5 | 0.00012 | apoptosis |
| NM_004994 | Matrix metallopeptidase 9 | 1.7 | 0.00001 | proteolysis |