Figure 5. The deleted region in the PAX6 protein is highly conserved among vertebrates. A: Diagrams of the wild type and mutant PAX6 proteins. Upper panel represents a human wild type PAX6 protein. The Lower panel represents a mutant. Due to the frameshift and COOH-terminal extension generated by the DNA deletion, the peptide in blue encoded by exon 14 of the wild type is replaced by the peptide in red in the mutant. B: Multiple alignment of PAX6 COOH-terminal sequences from different species of vertebrates. The box indicated that the deleted peptide shares 100% identity among vertebrates.