Figure 6. Protective effect of SP600125 on ocular hypertension-induced changes in retinal ganglion cell (RGC) density in the rat retina; “IOP elevation” corresponds to raising the intraocular pressure (IOP) to 45 mmHg for 7 h. A, B: Representative 40× images from the central (A) or peripheral (B) fields. The left-hand images are from control rats. The middle images are from IOP elevation + vehicle-treated rats. The right-hand images are from IOP elevation + SP600125 treated rats. Densities of RGC in the central (C) and peripheral (D) fields of the different study groups were quantified. Data are expressed as mean±SEM. Statistical significance was evaluated using a one-way ANOVA and a Bonferroni test.