Figure 2. Conservation of rhodopsin protein. The positions of previously reported mutations (p.T17M, p.Y178C, p.K296N, and p.P347L) were highly conserved across species. However, the position of newly identified p.A298D mutation was conserved in mammals. Accession numbers of the protein sequences used for sequence comparison were as follows: chimpanzee, XP_516740.2; monkey, XP_001094250.1; pig, NP_999386.1; rat, NP_254276.1; chicken, NP_990821.1; frog, NP_001080517.1; zebrafish, NP_571159.1. The arrowhead shows the position of missense mutations identified in the present study.