Figure 2. Pedigree of the family KTCN-014. Black-filled symbols: individuals with KTCN; open symbols: individuals without KTCN; gray-filled symbols: individuals with unknown KTCN status. Below each symbol the haplotypes are shown for the coding sequence in genes COL4A1, COL4A2 and UTRs between them. In COL4A1, the coding regions are surrounded by the markers rs13260 and col4a2_snp, and by rs35466678 and rs422733 in COL4A2, which were marked by a black frame. Haplotype regions in different colors indicate patterns of inheritance in the two branches in the pedigree.