Molecular Vision: Yip, Mol Vis 2011; 17:810-821. Table 5

Table 5. Allelic association tests of COL11A1 and COL18A1 SNPs genotyped individually.

	Alleles*		Genotype counts (11/12/22)*		HWE test (p value)		Minor allele freq		Allelic test†
SNP	1	2	Cases	Controls	Cases	Controls	Cases	Controls	OR (95% CI)	p value
*COL11A1*
rs17127311	A	G	206/74/5	165/89/2	0.8128	0.0054	0.1474	0.1816	– ‡	– ‡
*COL18A1*
rs2838922	C	T	197/75/26	174/91/28	4.47E-05	0.0047	0.2131	0.2509	– ‡	– ‡
rs11911327	C	T	197/89/10	192/97/7	1.0000	0.2524	0.1841	0.1875	0.98 (0.72 - 1.33)	0.8979
rs2236454	C	T	74/131/90	79/144/73	0.0621	0.6431	0.5271	0.4899	1.15 (0.92 - 1.44)	0.2132
rs2236457	C	T	183/94/22	180/93/14	0.0508	0.7221	0.2308	0.2108	1.10 (0.84 - 1.44)	0.5011
rs2236475	A	G	184/88/22	176/96/21	0.0187	0.1427	0.2245	0.2355	0.93 (0.71 - 1.20)	0.5672

*The major allele is designated as “1” and minor allele as “2”; and the genotype counts are indicated as the counts of the genotypes 11, 12, and 22, respectively. This study had 300 cases and 300 controls. Note that the total genotype counts may not add up to these expected numbers because a few samples failed to be genotyped in a random fashion. †The allelic test is performed with the gender as a covariate to adjust for the potential confounding by gender because the cases and controls differ significantly in the proportions of male and female subjects (p=4.30×10^–5).The odds ratio (OR) is calculated for the minor allele (allele 2) with the major allele (allele 1) as the reference. ‡ Association tests are not performed for these two SNPs (rs17127311 and rs2838922) because the genotypes in the controls are not in Hardy–Weinberg equilibrium (HWE).