Figure 5. Effect of BMP-2 on production of collagen I and aggrecan. The mRNA (A) and protein (B) expression levels for collagen I and aggrecan were significantly increased with 100 ng/ml BMP-2, 72 h in vitro. Bar graphs revealed changes in mRNA and protein expressions (mean±standard error of the mean) where values were stated as relative expression levels. C: control group, T: BMP-2 treatment group. The asterisk stands for p<0.05 and the double asterisk stands for p<0.01.