Table 1 of Hou, Mol Vis 2011; 17:627-637. Table 1 of Hou, Mol Vis 2011; 17:627-637.
Table 1. Antiproliferative compounds and potency profile.
Compound |
Cell line |
Minimum effective concentration tested (μM) |
IC50 (μM) |
Mean OD value of MTS reading at 1 μM |
p value* |
|---|---|---|---|---|---|
| PMEG | ARPE-19 | 10 | >50 | 1.01 | 0.0002 |
| 5-FU | ARPE-19 | 10 | 20 | 1.05 | <0.001 |
| DNR | ARPE-19 | 1 | 5 | 0.7 | 0.99 |
| HDP-PMEG | ARPE-19 | 0.1 | 10 | 0.71 | — |
| PMEG | EA-HY926 | 10 | 50 | 1.6 | <0.001 |
| 5-FU | EA-HY926 | 10 | 10 | 1.5 | <0.001 |
| DNR | EA-HY926 | 0.001 | 0.3 | 0.21 | 0.13 |
| HDP-PMEG | EA-HY926 | 0.01 | 0.05 | 0.36 | — |
| PMEG | MIO-M1 | 1 | >50 | 0.98 | 0.82 |
| 5-FU | MIO-M1 | 10 | >100 | 1.54 | <0.001 |
| DNR | MIO-M1 | 0.1 | 0.1 | 0.5 | 0.0142 |
| HDP-PMEG | MIO-M1 | 0.01 | 10 | 0.9 | — |
| PMEG | M23 | 0.1 | 50 | 1.51 | 0.0029 |
| 5-FU | M23 | 0.1 | 3 | 1.18 | 0.57 |
| DNR | M23 | 1 | 2 | 1.38 | 0.0301 |
| HDP-PMEG | M23 | 0.1 | 3 | 1.04 | — |
| PMEG | OCM1 | 10 | 50 | 2.26 | <0.001 |
| 5-FU | OCM1 | 1 | 20 | 1.81 | 0.012 |
| DNR | OCM1 | 0.1 | 1 | 0.93 | 0.064 |
| HDP-PMEG | OCM1 | 0.01 | 3 | 1.32 | — |
| PMEG | SP6.5 | 1 | 50 | 1.65 | 0.93 |
| 5-FU | SP6.5 | 1 | 10 | 1.55 | 0.99 |
| DNR | SP6.5 | 1 | 2 | 1.06 | 0.0682 |
| HDP-PMEG | SP6.5 | 1 | 5 | 1.56 | — |