Figure 3 of Manikandan, Mol Vis 2011; 17:388-394.


Figure 3. Effect of curcumin on αA- and αB-crystallin and heat shock protein 70 gene expression in the eye lens of Wistar rat pups exposed to selenium. Lane I, mRNA expression in lens from rat pups treated with saline alone (group I); lane II, mRNA expression in lens from rat pups administered with selenium alone (group II); lane III, mRNA expression in lens from rat pups administered with selenium and curcumin simultaneously (group III); lane IV, mRNA expression in lens from rat pups administered with selenium first and then treated with curcumin after 24 h (group IV); and lane V, mRNA expression in lens from rat pups pretreated with curcumin 24 h before selenium administration. Selenium-mediated oxidative stress causes an increase in the expression of αA- and αB-crystallin and Hsp 70 gene, which probably underlies the pathogenesis of cataractogenesis induced by selenium. All these changes were prevented by curcumin pretreatment, indicating its protective effect.