Figure 6. The statistical analysis results of bovine retinal capillary endothelial cells (BRCECs) intercellular adhesion molecule-1 (ICAM-1) gene expression relative to 18S rRNA for 24 h. Asymmetric dimethylarginine (ADMA) markedly upregulated ICAM-1 mRNA expression in BRCECs for 24 h. Benazepril, telmisartan, diphenyliodonium (DPI), or N-acetyl-l-cysteine (NAC) downregulated ICAM-1 mRNA expression in BRCECs exposed to ADMA. In group C, BRCECs were cultured in endothelial cell medium (ECM) with 0.4% fetal bovine serum (FBS). In group A, BRCECs were cultured in ECM with 0.4% FBS plus ADMA (100 μM). “A+B” represents same as for group A and 10 μM benazepril. In group “A+T,” BRCECs were cultured in the same media as group A and 10 μM telmisartan. In group “A+D,” BRCECs were cultured in the same media as group A and 10 μM DPI. In group “A+N,” BRCECs were cultured in the same media as group A and 10 mM NAC (mean±SD, n=3). **p<0.01 versus group C, ##p<0.01 versus group A.