Figure 1. Pedigree and homozygosity mapping of KKESH205. A: Pedigree of the KKESH205 family with LCA is shown. Affected, solid symbols; unaffected, open symbols; squares, male; circles, female. B: Homozygosity mapping of KKESH205 using high-density SNP arrays. The 11.2 Mb region, which is located on chromosome 15 (red box), is the only homozygous region shared by all three affected members in the whole genome.