Figure 1 of Zhou, Mol Vis 2011; 17:3415-3422.


Figure 1. Concentration-dependent inhibition by 17β-estradiol and progesterone of IL-1β–induced collagen degradation by corneal fibroblasts. Cells were cultured in collagen gels with (white bars) or without (gray bars) IL-1β (0.1 ng/ml) and in the presence of the indicated concentrations of 17β-estradiol or progesterone for 36 h, after which the amount of degraded collagen was determined. Data are expressed as micrograms of hydroxyproline (HYP) per well and are means±SEM of quadruplicates from an experiment that was repeated three times with similar results. *p<0.05 (Dunnett’s test) versus the corresponding value for cells cultured without female sex hormones.