Figure 5. Effect of VEGF and
Bevacizumab on proliferation of BCE cells. A, B:
Effect of different concentrations (0.1–2 mg/ml) of Bevacizumab
on proliferation of BCE cells. Increasing concentrations of
Bevacizumab (1–2 mg/ml) produce a significant decrease in cell
proliferation rates compared to controls. VEGF does not
significantly change BCE proliferation rates as compared to
controls. Cell proliferation was determined by the WST-1 assay
and automated cell counting. Proliferation rates are expressed
as percentages of control values. Proliferation rates under
serum-starved conditions were considered as positive controls;
BEV (Bevacizumab); V (vascular endothelial growth factor; VEGF).
* Indicates a significant decrease as compared to control
(p<0.05).