Figure 2. Schematic representation of pedigrees. For each pedigree, squares and circles denote males and females, respectively. Filled squares and circles denote that the individual had cataracts. Diagonal line denotes deceased family member. The proband for each pedigree is indicated by an arrowhead. A: Pedigree 1. For each participant, ‘+’ indicates presence of the CRYGD 109 C→A mutation (R36S) and ‘-‘ indicates a wildtype allele. Note that the heterozygous CRYGD mutation segregates with the dominant crystalline cataract phenotype. B: Pedigree 2. The affected mother and son harbor a heterozgous CRYGD 109 C→A mutation, while the unaffected father has two wildtype alleles.