Figure 5. The effect of amiloride or
psalmotoxin 1 on retinal ganglion cell death induced by
experimental hypoxia in vitro. Hypoxia significantly reduced the
survival of cultured retinal ganglion cells (RGCs) to 18.5±8.7%
(n=3), whereas amiloride treatment increased RGC survival to
72.3±12.6% (n=3). Although psalmotoxin 1 (PcTX1) did not affect
the current amplitude induced by acid under normal conditions,
PcTX1 treatment increased RGC survival to 36.9±13.7% (n=3) after
2 h of hypoxia (*p<0.05).