Table 4 of
Rose, Mol Vis 2011; 17:3243-3253. Table 4 of
Rose, Mol Vis 2011; 17:3243-3253.
Table 4. Predicted effects of the observed MYOC mutations on secondary structure, putative motifs, and modification sites of the myocilin protein.
| Mutation | Predicted effect of mutation on secondary structure and on motifs/modification sites |
|---|---|
| Gln48His | Loss of sheet, gain of turn near to the PKC site (44–46 amino acids) |
| Ser331thr | Change in predicted secondary structures of the mutant protein |
| Thr353Ile | Loss of PKC site at 353–355 |
| Pro370Leu | Loss of turn near to CK site (377–380) |
| Asn480Lys | Change in charge, gain of α-helix at CK2 site (475–478) |