Figure 6. Effects of mapracorat and dexamethasone on conjunctival symptoms induced by ovalbumin in guinea pigs. Mapracorat and dexamethasone eye drops were administered to guinea pigs actively immunized by i.p. injection of ovalbumin (OVA) and 2 weeks later challenged with OVA (30 µl of 2.5% solution) instilled into both eyes; 45 min before this challenge mapracorat (0.4%), dexamethasone (0.4%), or the vehicle (phosphate buffered saline) were instilled into both eyes (30 µl/eye). Controls received the vehicle alone and were not treated with OVA. Each group comprised five guinea pigs, and the score was based on changes before and 1,2, 4, and 6 h after challenge for the symptoms of itching, swelling, redness, and lid eversion as described under Methods. Data are presented as mean±standard error of the mean, n=10 (both eyes were evaluated). *Versus OVA or OVA+vehicle; p (value) p<0.05. **Versus OVA or OVA+vehicle; p<0.01. Abbreviations: Ctrl represents controls; OVA represents ovalbumin; DEX represents dexamethasone.