Figure 4. Effect of fibronectin
(FN)-siRNA on retinal FN protein expression. A:
Representative western blot image with an internal loading
control β–actin showing the effect of FN-siRNA on retinal FN
protein expression in diabetic rats. FN-siRNA treatment in the
diabetic rats specifically reduced retinal FN protein expression
compared to that in uninjected diabetic rats. B:
Graphical representation of retinal FN protein expression in
four groups of rats—normal, diabetic, diabetic injected with
FN-siRNA, and diabetic injected with scrambled siRNA—showing
that an intravitreal injection of FN-siRNA significantly reduces
FN protein expression in diabetic rat retinas. Normal versus
Diabetic *=p<0.05; Diabetic versus Diabetic+FN-siRNA
**=p<0.05, n=8.