Figure 3. Time course study showing
fibronectin (FN)–SiRNA efficacy. Relative levels of FN protein
in rat retinas at different time points (3 days–6 weeks) after
intravitreal injection of 3 μM FN–siRNA. By the 1-week time
point, retinal FN protein expression was significantly reduced
and remained inhibited at the 6-week time point. Scrambled siRNA
showed no effect on the FN protein level. *=p<0.05 versus “0
days” group mean; n=4/group.