Figure 2. Dose response study showing
fibronectin (FN)–siRNA efficacy. Different doses of FN-siRNA
were tested at a 1-week time point to identify an optimal dosage
for effective downregulation of FN expression. The graph shows
reduced FN levels in rat retinas after intravitreal injection
with increasing concentrations (0.5–6.0 μM) of FN–SiRNA. A 3 μM
dose was most effective at downregulating retinal FN protein
expression. *=p<0.05 versus “0 μM” group mean; n=4/group.