Figure 6. RAGE-Ig fusion protein inhibited the diabetes-induced hypersensitivity to tactile allodynia (light touch). Diabetic controls moved their legs at a lower pressure, indicating that they had increased sensitivity to touch. The inhibitor was administered at three doses of 10, 100, and 300 µg/day, and the duration of diabetes and drug administration was 2 months. n=6–10 in all groups.