Figure 4. RAGE-Ig fusion protein inhibited albumin accumulation in the neural retina. Diabetes resulted in a significant increase in the levels of immunoreactive albumin in the nonvascular retina (i.e., between vessels) in the A: outer nuclear layer, B: outer plexiform layer, C: inner nuclear layer, and D: inner plexiform layer. All three treatment doses doses normalized albumin leakage in all layers except in the inner plexiform layer, where only the two highest doses of the RAGE-Ig fusion protein significantly inhibited the leakage of albumin. n=6–10 in all groups.