Figure 1. Administration of the RAGE-immunoglobulin fusion protein for 10 months inhibited the diabetes-induced increase in degenerate, acellular capillaries. The inhibitor was administered at three doses, 10, 100, 300 µg/day, for the entire duration of the study. Pericyte loss (as indicated by ghosts where the pericytes used to be) also tended to be increased by diabetes, but the inhibitor did not significantly reduce their formation. All groups contained at least ten animals.