Figure 4. A selection of transmission electron micrographs from the corneal stroma of guinea pigs fed a normal (AA+) or ascorbic acid deficient (AA-) diet, with (UVB+) or without (UVB-) daily UV-B exposure. No clear differences in collagen fibril organization were evident between treatment groups and a disruption of cellular organelles was seen in all corneas (A-D). Regions devoid of regularly arranged collagen fibrils (arrows) were particularly evident in the UVB-treated corneas (C and D). Original magnification: 3000× (A, C, D) and 5000× (B).