Table 3 of Osborne, Mol Vis 2011; 17:3097-3106.

Table 3. Parental age at the birth of the anophthalmia subjects compared with parental age in the general population of births for England and Wales.



Parental age comparisons		 Number of
anophthalmia
subjects		 Parents of
anophthalmia
subjects		 Parental age
at birth for the
general population3		 Difference
in age
(years)

p value4
Deletions
Median (range) paternal age in years 8 30.0 (24.0–34.0) 32.1 (30.0–32.2) −2.11 0.19
Median (range) maternal age in years 8 24.5 (21.0–30.0) 27.5 (26.5–31.0) −3.01 0.17
Mutations
Median (range) paternal age in years 13 35.0 (18.0–44.0) 31.7 (29.7–32.4) +3.31 0.66
Median (range) maternal age in years 15 31.0 (18.0–41.0) 27.2 (25.1–32.4) +3.81 0.05
Paternal age
Median (range) paternal age in years of subjects with deletions 8 30.0 (24.0–34.0) - +5.02 0.22
Median (range) paternal age in years of subjects with mutation 13 35.0 (18.0–44.0) -    
Maternal age
Median (range) maternal age in years of subjects with deletions 8 24.5 (21.0–30.0) - +6.52 0.05
Median (range) maternal age in years of subjects with mutation 15 31.0 (18.0–41.0) -    

1The difference is the median parental age of anophthalmia subjects minus the median parental age in the general population. 2The difference is the median parental age of anophthalmia mutation cases minus the median parental age of anophthalmia deletion cases. 3Median of the birth year-specific general population means. 4P-values derived from the Mann–Whitney U test.

Osborne, Mol Vis 2011; 17:3097-3106. http://www.molvis.org/molvis/v17/a333

©2011 Molecular Vision http://www.molvis.org/molvis/

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