Figure 2. Effects of signaling inhibitors on IL-17A-induced CXCL8, CCL2, and IL-6 production in ARPE-19 cells. Cells were pretreated with PD98059 (PD), SB203580 (SB), LY29400 (LY) or PDTC at the indicated concentrations for 2 h, followed by incubation with or without 100 ng/ml IL-17A for 24 h. Secreted cytokines in supernatants were determined by ELISA. Values are expressed as the mean±SD of four independent experiments. *p<0.05, compared with the values in the absence of inhibitors.