Figure 1. Overview of the pedigree
structure of the Indonesian families participating in this
study. Affected individuals are indicated with filled symbols,
whereas unaffected relatives are indicated by open symbols.
Symbols with a slash depict deceased individuals. Probands are
indicated with arrows, and individuals that were genotyped on
genome-wide SNP arrays are marked with asterisks. Upon the
identification of mutations in the probands (gene and mutation
indicated below the pedigree), segregation analysis was
performed in all available relatives, the results of which are
indicated with M (mutated allele) or + (wild-type allele).