Molecular Vision: Zanon-Moreno, Mol Vis 2011; 17:2997-3004. Table 3

Table 3. Plasma vitamin A and vitamin C concentrations (mean±SD) depending on the corresponding RBP1, SLC23A1, or SLC23A2 genotypes in POAG cases and controls.

				Plasma concentration of vitamins
			Alleles*	Cases (n=150)					Controls (n=150)
Vitamin	Gene	SNP	(1/2)	1/1	1/2	2/2	p1	p2	1/1	1/2	2/2	p1	p2
Vitamin A (ng/ml)	RBP1	rs176990	T/G	521.5±44.0	518.9±49.4	518.2±47.1	0.947	0.847	539.8±43.1	528.4±62.6	519.8±60.9	0.361	0.256
Vitamin A (ng/ml)	RBP1	rs190910	A/T	516.0±37.3	519.9±50.0	520.9±48.7	0.907	0.804	523.6±51.1	528.2±62.6	528.8±57.3	0.935	0.871
Vitamin C (µg/ml)	SLC23A1	rs10063949	T/C	10.0±1.8	10.0±1.7	9.6±1.7	0.527	0.258	11.7±1.7	11.7±1.8	11.8±2.0	0.900	0.673
Vitamin C (µg/ml)	SLC23A2	rs1279683	A/G	10.3±1.7	10.6±1.6	9.0±1.4^a,b	<0.001**	<0.001**	12.0±1.9	12.1±1.8	10.9±1.6^c,d	0.001**	<0.001**

*Allele 1 is the ancestral allele. Allele 2 is the variant allele. **: Statistically significant p-value (p<0.0125) after the Bonferroni correction for multiple comparisons. p1: Uncorrected p-value obtained in the ANOVA test including the three genotypes. p2: Uncorrected p-value obtained in the Student's t-test comparing the homozygous subjects for the variant allele (2) with carriers of the ancestral allele (1/1+1/2). Bonferroni post-hoc comparisons: ^ap-values for comparison of means between vitamin C concentrations in GG subjects versus AA (uncorrected p<0.001; Bonferroni corrected p<0.001) in POAG cases. ^bp-values for comparison of means between vitamin C concentrations in GG subjects versus AG (uncorrected p<0.001; Bonferroni corrected p=0.001) in POAG cases. ^cp-values for comparison of means between vitamin C concentrations in GG subjects versus AA (uncorrected p=0.010; Bonferroni corrected p=0.038) in controls. ^dp-values for comparison of means between vitamin C concentrations in GG subjects versus AG (uncorrected p<0.001; Bonferroni corrected p=0.001) in controls. No significant differences were found between AA and AT genotypes for vitamin C concentrations.