Figure 1. Retinal DA and DOPAC levels and the DOPAC/DA ratio in normal control, FDM-only and defocus-only groups. DA and DOPAC concentrations were determined in retinal extracts at day 11 of treatment (FDM: deprived eyes; FDM fel: fellow eyes to deprived eyes; defocus: defocused eyes; defocus fel: fellow eyes to defocused eyes). The levels of retinal DA, DOPAC, and the DOPAC/DA ratio were significantly lower in the deprived eyes compared to their fellow eyes (* p<0.05, paired sample t-test). The levels of DA and DOPAC in the deprived eyes were significantly lower than in the normal control eyes (*p<0.05, one-way ANOVA). In contrast, the defocus-only group showed similar levels of DA and its metabolites between eyes of the individual animals (p>0.05, one-way ANOVA). However, the defocused eyes showed a significant reduction in retinal DOPAC level but no significant changes in DA or DOPAC/DA levels when compared to the normal control eyes (*p<0.05, one-way ANOVA).